Publications

24NRM03 MFMET II

REPORTS

  • 2026/01/13 –> Bertasiene, A., Batista, E., Yin, H., & Silverio, V. (2026). MFMET II A3.1.3 – Component selection based on measuring ranges, requirements and other key parameters for the subsequent use/application. https://doi.org/10.5281/zenodo.18267678
  • 2025/12/16 –> Yildirim, E., Büker, O., Silverio, V., Batista, E., & Becker, H. (2025). MFMET II A3.4.1 – Literature survey on Microfluidic Bonding Strength. https://doi.org/10.5281/zenodo.17953814
  • 2025/12/10 –> Yıldırım, E., Batista, E., Tzannis, A. P., Zhang, N., & Crabtree, H. J. (2026). MFMET II A2.1.1 Update EMPIR 20NRM02 MFMET database on Sensors and Actuators. https://doi.org/10.5281/zenodo.18154632
  • 2025/12/04 –> Yin, H., Bernier, M., Silverio, V., Daugbjerg, T., Batista, E., & Büker, O. (2025). MFMET II A3.1.1 – Review of microfluidic devices and components on the market. https://doi.org/10.5281/zenodo.17814608
  • 2025/12/02 –> Batista, E., Silverio, V., Ribeiro, A. S., Martins, L. L., Bernien, M., & Büker, O. (2025). MFMET II A3.1.2 – Study of the state of the art including the differences and practical issues associated with the use of gas vs liquid. https://doi.org/10.5281/zenodo.17792267
  • 2025/11/28 –> Ogheard, F., Batista, E., Büker, O., Daugbjerg, T. S., Romieu, K., & Silverio, V. (2026). MFMET II A1.2.1 – Review of existing standardised methods for characterising pressure drop and flow resistance. https://doi.org/10.5281/zenodo.18155039
  • 2025/11/28 –> Ogheard, F., Daugbjerg, T. S., Batista, E., Silverio, V., Yildirim, E., Romieu, K., & Kartmann, S. (2026). MFMET II A1.1.2 – Selection of parameters for particle-laden flows experiments and simulations. https://doi.org/10.5281/zenodo.18154963
  • 2025/11/26 –> Batista, E. (2026). MFMET II A4.1.1 – Identification of possible biological topics/quantities that require metrological sound measurements. https://doi.org/10.5281/zenodo.18154767
  • 2025/11/24 –> Ogheard, F., Batista, E., Loessberg-Zahl, J., Romieu, K., Dulk, R. den ., & Kartmann, S. (2025). MFMET II A4.1.2 – Selection of physical and biological quantities. Zenodo. https://doi.org/10.5281/zenodo.17701414
  • 2025/09/29 –> Batista, E., Silverio, V., Romieu, K., & Büker, O. (2025). MFMET II A3.3.1 – Literature survey on requirements and procedures with regards to burst pressure. https://doi.org/10.5281/zenodo.17224659
  • 2025/09/12 –> Batista, E., Silverio, V., Daugbjerg, T. S., Kartmann, S., Yildirim, E., Ogheard, F., Ribeiro, A., & Bertašienė, A. (2025). MFMET II A1.1.1: Review different types of particles and generation of particle-laden flows relevant for microfluidics technology. https://doi.org/10.5281/zenodo.17120472
  • 2025/09/11 –> Batista, E., Daugbjerg, T.S., Ribeiro, A.S., Coelho, G.E., & Silverio, V. (2025) MFMET II A3.2.1: literature survey on requirements and procedures with regard to leakage in a range 30 °C < T < 75 °C. https://doi.org/10.5281/zenodo.17100736

PEER REVIEWED SCIENTIFIC PUBLICATIONS

NEWSLETTERS

  • 2026/01/09 –> 2nd MFMET II Newsletter can be found here
  • 2025/07/04 –> 1st MFMET II Newsletter can be found here

PUBLISHABLE SUMMARIES

  • 2025/05/27 –> 1st MFMET II publishable summary. Link

IN THE PRESS

  • 2025/10/14 –> MFMET II Flyer. Link
  • 2025/06/27 –> Press statement MFMET II. Link

EVENTS

  • 2025/11/29 –> Standardization of Measurements in Microfluidics and Organ-on-Chip: Pathways Toward Universally Accessible Science and Technology, Vania Silverio, CONFMET2025, Caparica, Portugal
  • 2025/11/29 –> The Importance of Metrology and Standardization in the Development of Organ-on-Chip – MFMET II Project, Elsa Batista; Isabel Godinho; Sara Moura; Fernanda Saraiva; Maria do Céu Ferreira; Marta Serra; António Capela; Vania Silverio; Álvaro Ribeiro, CONFMET2025, Caparica, Portugal
  • 2025/06/09-13 –> Establishing metrology standards in microfluidic devices: project impact and future work, Elsa Batista, Vania Silverio, João Alves e Sousa, Kevin Romieu, Thomas Schrøder Daugbjerg, Oliver Büker, iMPSS – MPS World Summit 2025, Brussels, Belgium Link

Zenodo Repository

20NRM02 MFMET

INPUT TO STANDARDS

  • ISO/TS 6417:2025 Microfluidic pumps — Symbols and performance communication. Link
  • ISO/TR 6037:2024 Automated liquid handling systems – Uncertainty of the measurement procedures. Link
  • CEN/CENELEC FGOoC Focus Group Organ-on-Chip Standardization Roadmap. 2024/07. Link
  • ISO 10991:2023 Microfluidics Vocabulary. Link
  • ISO 22916:2022 Microfluidic devices — Interoperability requirements for dimensions, connections and initial device classification. Link
  • ISO 23783-1:2022 Automated liquid handling systems Part 1: Vocabulary and general requirements. Link
  • ISO 23783-2:2022 Automated liquid handling systems Part 2: Measurement procedures for the determination of volumetric performance. Link
  • ISO 23783-3:2022 Automated liquid handling systems Part 3: Determination, specification and reporting of volumetric performance. Link

DELIVERABLES

  • 2024-05-30 –> Deliverable 2 – Guidelines for the implementation of consensus-based flow control specifications in the microfluidics industry supply chain. Link
  • 2024-05-09 –> Deliverable 4 – Report on test protocols for liquid properties in microfluidic devices for use in pharmaceuticals, biomedical and mechanobiology applications. Link
  • 2024-05-09 –> Deliverable 3 – Calibration guide for the evaluation of flow-related quantities in microfluidic devices. Link
  • 2024-04-30 –> Deliverable 8 – Measurement protocols for dimensional characterisation of microfluidic components. Link
  • 2024-04-05 –> Deliverable 7 – Landscape document identifying standardization requirements for microfluidic component design and manufacturing with respect to modularity and heterogenous integration. Link
  • 2023-11-29 –> Deliverable 6 – Guidelines for the implementation of standardised methods of microfluidic components focusing on port connection from microscale fluidic channels to the macroscale world and associated changes in flow and pressure. Link
  • 2023-11-29 –> Deliverable 5 – Guidelines for the measurement of key performance parameters of microfluidic connections including the identification of key properties in an interface. Link
  • 2023/05/05 –> Deliverable 1 – Guidelines and a test protocol for flow control evaluating leakage and burst pressure in microfluidic devices. Link

WEBINAR

  • MFMET webinar – 01. The role of Metrology and Standardization in microfluidic technology development. Link
  • MFMET webinar – 02. Flow in microfluidics. Link
  • MFMET webinar – 03. Wettability and surface roughness. Link
  • MFMET webinar – 04. Leakage in Microfluidic Devices – detection and quantification. Link
  • MFMET webinar – 05. Interfacing of microfluidic devices. Link
  • MFMET webinar – 06. Measuring the dimensions of microfluidic devices using optical methods. Link

REPORTS

  • 2024/09/17 –> Final Publishable Report. Link
  • 2024/05/31 –> A2.4.3 Documented example of the leakage transfer standards test. Link
  • 2024/05/31 –> A2.4.4 Technical report describing the design, fabrication, and calibration process of the transfer standards. Link
  • 2024/05/30 –> A1.1.5 – Communication report on the definition of flow control concepts terms and components used in microfluidics and related database. Link
  • 2024/05/27 –> A5.1.7 Report on reasons for failure of microfluidic devices. Link
  • 2024/05/09 –> A3.2.5 Documented example of wettability test protocol. Link
  • 2024/04/30 –> A2.2.3 Documented example of the test protocol for hydrodynamic resistance, flow rate and volume. Link
  • 2024/03/21 –> A3.3.4 Report on the geometry and dimension of microfluidic component ports. Link
  • 2024/03/21 –> A4.1.4 Current state of the art of modularity and heterogenous integration of microfluidic systems. Link
  • 2024/01/09 –> A1.3.5 Gaps in microfluidic flow control methodologies. Link
  • 2023/11/12 –> A1.3.2 Existing operational conditions and existing operation protocols for flow control. Link
  • 2023/11/12 –> A1.3.1 Investigation on the State-of-the-art of available methodologies for flow control (nano/micro/meso/macro fluidics). Link
  • 2023/11/11 –> A1.2.3 Documented example of the test protocol for leakage and burst pressure. Link
  • 2023/09/19 –> A1.1.4 Generic specification list for comparison of flow control components. Link
  • 2023/08/30 –> A1.1.3 Using the Database/inventory for flow control components. Link, Link
  • 2023/06/01 –> A3.2.7 Documented example of surface roughness measurements. Link
  • 2023/04/03 –> A2.2.2 Development of test protocols for microfluidic devices. Link
  • 2023/04/03 –> A2.3.2 Test protocols for liquid properties related to microfluidic devices. Link
  • 2022/09/19 –> A1.1.2 Definitions Symbols and Vocabulary of Flow Control. Link
  • 2022/07/15 –> A1.1.1 Literature and market research: definitions, characteristics, specifications, application and function of flow control components. Link
  • 2022/05/24 –> A2.2.1 Literature review of existing metrology and normative standards related to the flow properties and microfluidic devices. Link
  • 2022/04/05 –> A2.3.1 Literature review of existing metrology and normative standards related to the liquid properties and microfluidic devices. Link
  • 2022/03/04 –> A2.1.1 Metrology Methodology. Link
  • 2022/02/28 –> Results from Microfluidics Surveys

* 2021/09/23 – Microfluidics Leakage – The Microfluidics Association
* 2015/11 Microfluidics Flow Control – enablingMNT
* 2015/03 Reliability of Microfluidics based Devices and Components – enablingMNT
* 2014/09 Microfluidic Interconnections and Chips – enablingMNT

PROTOCOLS

  • 2022/12/07 –> A3.2.4 Test protocol for surface roughness. Link
  • 2022/06/01 –> The MFA & MFMET – Protocols for leakage testing. Link

WHITE PAPERS

  • van Heeren H, Silverio V, Batista E, Reyes D (January 2024) On the road to standardization in Microfluidics and Organ-on-Chip. Link
  • van Heeren H, Pecnik C, Silverio V, Batista E, Yin H, Akselli B, Ogheard F (May 2023) Common microfluidic components materials: properties and fabrication. Link
  • Copeland M, Ogheard F, Batista E, van Heeren H (May 2023) Flow resistivity testing. Link
  • Pecnik C, van Heeren H, Yin H (April 2023) Guidelines for Optical Interfaces of Microfluidic Devices. Link
  • van Heeren H, Davies M, Keiser A, Lagrauw R, Reyes DR, Silverio V, Verplanck N (May 2022) Protocols for leakage testing. Link
  • Akselli B, Batista E, Furtado A, van Heeren H, Moura S, Ogheard F, Pecnik C, Silverio V, Yin H, Zhang N, Zhao H (October 2022) Measurement of hydrophobicity, hydrophilicity, and wettability. Link

PEER REVIEWED SCIENTIFIC PUBLICATIONS

  • Kaal J, Feltin N, Lelong M, Yin H, Glidle A, Romieu K, Batista E (2025) Comparison of Measurement Protocols for Internal Channels of Transparent Microfluidic Devices, Metrology 5(1), 4; https://doi.org/10.3390/metrology5010004
  • Batista E, Silverio V, Romieu K, Alves e Sousa J, Daugbjerg TS (2024) Development of measurement procedures for volume and flow related quantities in microfluidic devices. Measurement: Sensors 101551 https://doi.org/10.1016/j.measen.2024.101551
  • Büker O, Stolt K, Batista E, Sepulveda J, Giuliano CB, Morin A, Nobre D, Navas H (2024) Investigations on the performance of a newly developed pressure-driven flow controller used in microfluidic applications. Measurement: Sensors 101645 https://doi.org/10.1016/j.measen.2024.101645
  • Lima J, Furtado A, Batista E, Moura S, Navas H, Pellegrino O (2024) Determining Liquid Properties for Application in Microfluidic Devices. TMQ – Techniques, Methodology and Quality 15:147-165. ISSN 2183-0940. https://publicacoes.riqual.org/ed15-147-165
  • Batista E, Sousa JA, Saraiva F, Lopes A, Silverio V, Martins R, Martins L (2024) The importance of dimensional traceability in microfluidic systems. Metrology 4:240–253. https://doi.org/10.3390/metrology4020015
  • Gil JF, Moura CS, Silverio V, Gonçalves G, Santos HA (2023) Cancer models on chip: paving the way to large scale trial applications. Advanced Materials 2300692, 26 pp. https://doi.org/10.1002/adma.202300692
  • Caetano DM, Afonso R, Soares AR, Silva J, Busse HI, Silverio V, Rabuske T, Tavares G, Fernandes JR, Cardoso S (2023) Artificial Neural Networks for GMR-Based Magnetic Cytometry. IEEE Transactions on Instrumentation & Measurement 72:1-11, 2506911, https://doi.org/10.1109/TIM.2023.3244208
  • Silverio V, Guha S, Keiser A, Natu R, Reyes DR, van Heeren H, Verplanck N, Herbertson LH (2022) Overcoming Technological Barriers in Microfluidics: Leakage Testing. Frontiers in Bioengineering and Biotechnology, 10:958582. https://doi.org/10.3389/fbioe.2022.958582

NEWSLETTERS

  • 2024/05/31 –> 6th MFMET Newsletter can be found here
  • 2024/01/05 –> 5th MFMET Newsletter can be found here
  • 2023/08/09 –> 4th MFMET Newsletter can be found here
  • 2022/12/12 –> 3rd MFMET Newsletter can be found here
  • 2022/07/15 –> 2nd MFMET Newsletter can be found here
  • 2022/01/19 –> 1st MFMET Newsletter can be found here

PUBLISHABLE SUMMARIES

  • 2024/09/17 –> Final MFMET publishable summary. Link
  • 2023/11/03 –> 3rd MFMET publishable summary. Link
  • 2023/02/16 –> 2nd MFMET publishable summary. Link
  • 2021/06/30 –> 1st MFMET publishable summary. Link

EVENTS

MFMET IN THE MEDIA

 

Zenodo Repository

2023/08/29