Publications

INPUT TO STANDARDS

ISO/DTS 6417 Microfluidic pumps — Symbols and performance communication. Link
ISO/DTR 6037 Automated liquid handling systems – Uncertainty of the measurement procedures. Link
ISO 10991:2023 Microfluidics Vocabulary. Link
ISO 22916:2022 Microfluidic devices — Interoperability requirements for dimensions, connections and initial device classification. Link

DELIVERABLES

2024-05-30 –> Deliverable 2 – Guidelines for the implementation of consensus-based flow control specifications in the microfluidics industry supply chain. Link
2024-05-09 –> Deliverable 4 – Report on test protocols for liquid properties in microfluidic devices for use in pharmaceuticals, biomedical and mechanobiology applications. Link
2024-05-09 –> Deliverable 3 – Calibration guide for the evaluation of flow-related quantities in microfluidic devices. Link
2024-04-30 –> Deliverable 8 – Measurement protocols for dimensional characterisation of microfluidic components. Link
2024-04-05 –> Deliverable 7 – Landscape document identifying standardization requirements for microfluidic component design and manufacturing with respect to modularity and heterogenous integration. Link
2023-11-29 –> Deliverable 6 – Guidelines for the implementation of standardised methods of microfluidic components focusing on port connection from microscale fluidic channels to the macroscale world and associated changes in flow and pressure. Link
2023-11-29 –> Deliverable 5 – Guidelines for the measurement of key performance parameters of microfluidic connections including the identification of key properties in an interface. Link
2023/05/05 –> Deliverable 1 – Guidelines and a test protocol for flow control evaluating leakage and burst pressure in microfluidic devices. Link

WEBINAR

MFMET webinar – 01. The role of Metrology and Standardization in microfluidic technology development. Link
MFMET webinar – 02. Flow in microfluidics. Link
MFMET webinar – 03. Wettability and surface roughness. Link
MFMET webinar – 04. Leakage in Microfluidic Devices – detection and quantification. Link
MFMET webinar – 05. Interfacing of microfluidic devices. Link
MFMET webinar – 06. Measuring the dimensions of microfluidic devices using optical methods. Link

REPORTS

2024/09/17 –> Final Publishable Report. Link
2024/05/31 –> A2.4.3 Documented example of the leakage transfer standards test. Link
2024/05/31 –> A2.4.4 Technical report describing the design, fabrication, and calibration process of the transfer standards. Link
2024/05/30 –> A1.1.5 – Communication report on the definition of flow control concepts terms and components used in microfluidics and related database. Link
2024/05/27 –> A5.1.7 Report on reasons for failure of microfluidic devices. Link
2024/05/09 –> A3.2.5 Documented example of wettability test protocol. Link
2024/04/30 –> A2.2.3 Documented example of the test protocol for hydrodynamic resistance, flow rate and volume. Link
2024/03/21 –> A3.3.4 Report on the geometry and dimension of microfluidic component ports. Link
2024/03/21 –> A4.1.4 Current state of the art of modularity and heterogenous integration of microfluidic systems. Link
2024/01/09 –> A1.3.5 Gaps in microfluidic flow control methodologies. Link
2023/11/12 –> A1.3.2 Existing operational conditions and existing operation protocols for flow control. Link
2023/11/12 –> A1.3.1 Investigation on the State-of-the-art of available methodologies for flow control (nano/micro/meso/macro fluidics). Link
2023/11/11 –> A1.2.3 Documented example of the test protocol for leakage and burst pressure. Link
2023/09/19 –> A1.1.4 Generic specification list for comparison of flow control components. Link
2023/08/30 –> A1.1.3 Using the Database/inventory for flow control components. Link, Link
2023/06/01 –> A3.2.7 Documented example of surface roughness measurements. Link
2023/04/03 –> A2.2.2 Development of test protocols for microfluidic devices. Link
2023/04/03 –> A2.3.2 Test protocols for liquid properties related to microfluidic devices. Link
2022/09/19 –> A1.1.2 Definitions Symbols and Vocabulary of Flow Control. Link
2022/07/15 –> A1.1.1 Literature and market research: definitions, characteristics, specifications, application and function of flow control components. Link
2022/05/24 –> A2.2.1 Literature review of existing metrology and normative standards related to the flow properties and microfluidic devices. Link
2022/04/05 –> A2.3.1 Literature review of existing metrology and normative standards related to the liquid properties and microfluidic devices. Link
2022/03/04 –> A2.1.1 Metrology Methodology. Link
2022/02/28 –> Results from Microfluidics Surveys

* 2021/09/23 – Microfluidics Leakage – The Microfluidics Association
* 2015/11 Microfluidics Flow Control – enablingMNT
* 2015/03 Reliability of Microfluidics based Devices and Components – enablingMNT
* 2014/09 Microfluidic Interconnections and Chips – enablingMNT

PROTOCOLS

2022/12/07 –> A3.2.4 Test protocol for surface roughness. Link
2022/06/01 –> The MFA & MFMET – Protocols for leakage testing. Link

WHITE PAPERS

van Heeren H, Silverio V, Batista E, Reyes D (January 2024) On the road to standardization in Microfluidics and Organ-on-Chip. Link
van Heeren H, Pecnik C, Silverio V, Batista E, Yin H, Akselli B, Ogheard F (May 2023) Common microfluidic components materials: properties and fabrication. Link
Copeland M, Ogheard F, Batista E, van Heeren H (May 2023) Flow resistivity testing. Link
Pecnik C, van Heeren H, Yin H (April 2023) Guidelines for Optical Interfaces of Microfluidic Devices. Link
van Heeren H, Davies M, Keiser A, Lagrauw R, Reyes DR, Silverio V, Verplanck N (May 2022) Protocols for leakage testing. Link
Akselli B, Batista E, Furtado A, van Heeren H, Moura S, Ogheard F, Pecnik C, Silverio V, Yin H, Zhang N, Zhao H (October 2022) Measurement of hydrophobicity, hydrophilicity, and wettability. Link

PEER REVIEWED SCIENTIFIC PUBLICATIONS

Lima J, Furtado A, Batista E, Moura S, Navas H, Pellegrino O (2024) Determining Liquid Properties for Application in Microfluidic Devices. TMQ – Techniques, Methodology and Quality 15:147-165. ISSN 2183-0940. https://publicacoes.riqual.org/ed15-147-165
E. Batista, J. A. Sousa, F. Saraiva, A. Lopes, V. Silverio, R. Martins, L. Martins (2024) The importance of dimensional traceability in microfluidic systems. Metrology 4:240–253. https://doi.org/10.3390/metrology4020015
J.F. Gil, C.S. Moura, V. Silverio, G. Gonçalves, H.A. Santos (2023) Cancer models on chip: paving the way to large scale trial applications. Advanced Materials 2300692, 26 pp. https://doi.org/10.1002/adma.202300692
D.M. Caetano, R. Afonso, A.R. Soares, J. Silva, H.I. Busse, V. Silverio, T. Rabuske, G. Tavares, J.R. Fernandes, S. Cardoso (2023) Artificial Neural Networks for GMR-Based Magnetic Cytometry. IEEE Transactions on Instrumentation & Measurement 72:1-11, 2506911, https://doi.org/10.1109/TIM.2023.3244208
V. Silverio, S. Guha, A. Keiser, R. Natu, D.R. Reyes, H. van Heeren, N. Verplanck, L.H. Herbertson (2022) Overcoming Technological Barriers in Microfluidics: Leakage Testing. Frontiers in Bioengineering and Biotechnology, 10:958582. https://doi.org/10.3389/fbioe.2022.958582

NEWSLETTERS

2024/05/31 –> 6th MFMET Newsletter can be found here
2024/01/05 –> 5th MFMET Newsletter can be found here
2023/08/09 –> 4th MFMET Newsletter can be found here
2022/12/12 –> 3rd MFMET Newsletter can be found here
2022/07/15 –> 2nd MFMET Newsletter can be found here
2022/01/19 –> 1st MFMET Newsletter can be found here

PUBLISHABLE SUMMARIES

2024/09/17 –> Final MFMET publishable summary. Link
2023/11/03 –> 3rd MFMET publishable summary. Link
2023/02/16 –> 2nd MFMET publishable summary. Link
2021/06/30 –> 1st MFMET publishable summary. Link

EVENTS

2024/06/10-14 –> Accelerating cell-based high-throuput screening with a novel standardized 96-wells fluidic system with interchangeable cell culture, Vania Silverio, INESC MN, Portugal in the iMPSS – MPS World Summit 2024, Seattle, USA
2024/06/10-14 –> Development of technical procedures for traceable and accurate measurements of volume and flow related quantities in microfluidic devices, Vania Silverio, INESC MN, Portugal in the iMPSS – MPS World Summit 2024, Seattle, USA
2024/06/09-10 –> Standardizing the Future of Microfluidics: The Crucial Role of MFMET, Vania Silverio, INESC MN, Portugal, in the iMPSS – MPS World Summit 2024 – Workshop for Advancing Standards and Regulatory Science for MPS and Microfluidic-based Medical Products, Seattle, USA
2024/05/16 –> MFMET – Summary : Measurement technologies for microfluidics, Vania Silverio, INESC MN, Portugal, in the UNLOOC Standardization Workshop, Jena, Germany
2023/11/23 –> MFMET – A success story from a pre-standardisation research project, Elsa Batista, IPQ, Portugal, in the Workshop on the Future of Metrology, Brussels, Belgium
2023/06/27-30 –> The importance of traceability in dimensional metrology in microfluidic systems by Elsa Batista, IPQ, and Vania Silverio, INESC MN, Portugal, in the 2nd Microphysiological Systems World Summit -MPS2023. Berlin, Germany. Poster
2023/06/26 –> Establishing metrology standards in microfluidic devices, MFMET EMPIR project by Elsa Batista, IPQ, Portugal, in the FG Standards for Organ-on-Chip, 2nd Microphysiological Systems World Summit -MPS2023. Berlin, Germany
2023/06/26 –> Establishing metrology standards in microfluidic devices, MFMET by Vania Silverio, Portugal, in the ECVAM workshop: Heads on! Designing a qualification framework for Organ-on-Chip, 2nd Microphysiological Systems World Summit -MPS2023. Berlin, Germany
2023/05/07-10 –> Establishing Metrology Standards in Microfluidic Devices by Florestan Ogheard, CETIAT, France, in the 21st International Metrology Congress – CIM2023. Lyon, France
2023/03/28-29 –> Accelerating Innovation of Microfluidic Technology – the Role of Standardization. Presentation by Vania Silverio, INESC MN, Portugal, in the Workshop on BioMEMS and Microfluidic Technologies. Ankara, Turkey
2022/11/30 –> Microfluidics Standards – MFMET project. Presentation by Vania Silverio, INESC MN, Portugal, in the Microfluidics Consortium Open Day – Enschede Holland. Enschede, The Netherlands
2022/11/7-9 –> A path to standardization in microfluidics: transforming challenges into opportunities for a universal tool. Presentation by Vania Silverio, INESC MN, Portugal in the III Brazil-Argentine Microfluidics Congress and VI Congreso de Microfluídica Argentina. Buenos Aires, Argentina
2022/07/4-5 –> Influence of Microfluidic Standards on Organs-on-Chips. Poster by Batista E, van Heeren H, Ogheard F, Silverio V, Kaal J, Verplanck N. EUROoCS 2022, Grenoble, France. Poster can be downloaded here
2022/05/05 –> Metrology supports microfluidic fabrication and testing, Presentation by Elsa Batista, IPQ, Portugal in The road to user friendly and standardized integration of microfluidic components and devices, The Microfluidics Association
2021/09/7-9 –> A new EURAMET EMPIR Project: establishing metrology standards in microfluidic devices. Poster by Ogheard F, Batista E, Silverio V, Pecnik C, Becker H, Graham E. CIM 2021, Lyon, France. Poster can be downloaded here

MFMET IN THE MEDIA

MSD Staff Writer. Setting the standard. Medical Device Developments. November 18, 2022. link
NS Energy Staff Writer. Setting the standard. NS Medical Devices, November 02, 2022. link
H. van Heeren. The lack of standard metrology tools impedes the pace of microfluidics development. Photonics, May 20, 2022. link
H. van Heeren, V. Silverio, C. Pecnik, E. Batista. Metrology Challenges for Microfluidics. Commercial Micro Manufacturing Magazine, April 13, 2022. link

Zenodo Repository

_2023/08/29